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Search Results for " sodium-channel blocker "

69

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0440	Oxcarbazepine GP 47680,奥卡西平	Apoptosis; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oxcarbazepine (GP 47680) 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。
T0866	Propafenone Rythmol,普罗帕酮,Propafenonum	Potassium Channel; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel
	Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。
T7806	Licarbazepine 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平	Others	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂，具有抗惊厥和稳定情绪的功效。
T79835	Aneratrigine hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Aneratrigine hydrochloride 是一种钠通道蛋白9型亚基阻断剂，可用于预防或治疗钠通道阻断剂相关疾病。
T31614	Elpetrigine GW-273293,JZP 4,JZP4,GW273293,JZP-4,GW 273293
	Elpetrigine( GW 273293, JZP-4) is effective calcium and sodium channel blocker and is currently being evaluated in patients as an anticonvulsant and mood stabilizer.
T22675	Co 102862 V 102862	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Co 102862 是一种电压门控钠通道阻滞剂。 Co 102862 可用于抗惊厥的研究。
T31716	Etidocaine Hydrochloride W-19053,Duranest,W19053,W 19053	Sodium Channel	Membrane transporter/Ion channel
	Etidocaine Hydrochloride (W19053) 是一种长效麻醉剂和电压门控钠通道阻滞剂。
T7182	Metaflumizone BAS-320I,氰氟虫腙	Sodium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Metaflumizone (BAS-320I) 是一种缩氨基脲杀虫剂，是钠离子通道阻滞剂。
T7811	Pilsicainide HCl SUN 1165,盐酸吡西卡呢	Sodium Channel	Membrane transporter/Ion channel
	Pilsicainide HCl (SUN 1165) 是一种纯钠通道阻滞剂。
T12608	QX-314 chloride	Sodium Channel	Membrane transporter/Ion channel
	QX-314 chloride 是钠离子通道电荷阻滞剂，具有膜不渗透性。
T13177L	Tocainide	Sodium Channel	Membrane transporter/Ion channel
	Tocainide 是口服有活性的 sodium channel 阻滞剂，阻断产生疼痛的病灶中(神经膜上)的钠通道。它是利多卡因 (lignocaine) 的伯胺类似物，可用于研究心律不齐。
T2523	Rufinamide CGP 33101,E 2080,卢非酰胺,RUF 331	Sodium Channel	Membrane transporter/Ion channel
	Rufinamide (E 2080) 是一种新型镇痫化合物，可用于研究 Lennox-Gastaut 综合症。
T23213	QX-222 chloride QX 222,Lidocaine N-Methyl Hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	QX-222 chloride (Lidocaine N-Methyl Hydrochloride) 是 Lignocaine 的一种三甲基类似物，是有效的 Na+通道阻滞剂。
T68143	Solpecainol	Sodium Channel	Membrane transporter/Ion channel
	solpecainol 是一种钠离子通道阻滞剂，可用于研究神经系统和心血管疾病。
T1041	Risedronate Sodium NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠	HBV; Transferase	Metabolism; Microbiology/Virology
	Risedronate Sodium (NE 58095 Sodium) 是一种双磷酸盐，对破骨细胞介导的骨吸收具有抑制作用。
T12424	PF-06305591 PF-6305591	Others	Others
	PF-06305591是一种有效的、选择性的电压门钠通道NaV1.8的阻断剂（IC50=15 nM）。
T7066	Fosphenytoin disodium Fosphenytoin sodium,ACC-9653,磷苯妥英钠	Sodium Channel	Membrane transporter/Ion channel
	Fosphenytoin disodium (ACC-9653) 是 phenytoin 的前体药物，具有抗惊厥等活性。它是电压门控钠通道阻滞剂。
T5850	Benzamil Benzamil (hydrochloride)	Na+/Ca2+ Exchanger; Sodium Channel	Membrane transporter/Ion channel
	Benzamil 是 Amiloride 类似物，是 Na+/Ca2+交换体抑制剂，抑制 TRPP3 介导的 Ca2+激活电流，IC50为 1.1 μM。它也是一种非选择性上皮钠通道 (ENaC) 阻滞剂，能增强肌源性血管收缩。
T27830L	Lifarizine FA Lifarizine FA(119514-66-8 Free base)	Sodium Channel	Membrane transporter/Ion channel
	Lifarizine FA 是一种钠通道阻滞剂，可用于治疗神经系统疾病和心血管疾病，研究脑卒中。
T15260	Evenamide NW-3509	Sodium Channel	Membrane transporter/Ion channel
	Evenamide (NW-3509) 是一种口服有效的电压门控钠通道 (sodium channel, VGSC) 阻滞剂，Ki 为 0.4 µM，在精神分裂症中有研究价值。Evenamide 在精神病，躁狂症，抑郁和攻击性的各种啮齿动物模型中具有显著功效。
T39630	Zandatrigine NBI-921352,XEN901	Sodium Channel	Membrane transporter/Ion channel
	Zandatrigine (NBI-921352) 是钠通道蛋白 8 型亚基 α 的阻断剂，可用于癫痫治疗的神经系统病理学研究。
T29457L	5-Hydroxydecanoate sodium	Potassium Channel	Membrane transporter/Ion channel
	5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂，IC50 约为 30 μM。它是线粒体外膜酰基辅酶A 合成酶的底物，具有抗氧化性。
T13177	Taquidil
	Tocainide hydrochloride 是一种sodium channel 阻滞剂，它阻断神经膜中产生疼痛的病灶中的钠通道。Tocainide hydrochloride 是利多卡因 (lignocaine) 的一种伯胺类似物，可有效抑制各种情况下的室性心律失常。
T9234	Tocainide hydrochloride 2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) 是利多卡因的伯胺类似物，是钠通道阻滞剂，在产生疼痛的病灶中(神经膜上) 阻断钠通道。Tocainide hydrochloride 具有用于心律不齐研究的价值。
T5391	Bepridil hydrochloride CERM 1978,盐酸苄普地尔	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Bepridil hydrochloride (CERM 1978) 是一种钙通道阻滞剂，还抑制 Na+/Ca2+ 交换(NCX)、钠通道和心脏肌膜 KATP 通道，具有抗心绞痛的作用。
T0024	Primidone Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360	GABA Receptor; Sodium Channel; GluR; AChR	Membrane transporter/Ion channel; Neuroscience
	Primidone (NCI-C56360) 是一种强效抗惊厥试剂。它是神经元性电压门控钠通道阻滞剂，在癫痫、原发性震颤和精神疾病的研究中具有价值。
T0119	Nitrendipine BAY-E-5009,Bayotensin,尼群地平	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Nitrendipine (BAY-E-5009) 是 Nifedipine 的类似物，是一种钙通道阻滞剂，具有显着的血管扩张作用。它是一种有效的抗高血压药且不会降低肾小球滤过率，并且具有轻微的利钠作用。
T1046	Mexiletine hydrochloride KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律	AhR; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂，是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流，从而降低心脏动作电位（0相）上升速率，并且降低浦肯野纤维的自律性而发挥抗心律失常作用。
T7502	PF 05089771 tosylate	Sodium Channel	Membrane transporter/Ion channel
	PF 05089771 tosylate 是口服有效的、选择性的Nav1.7丙烯酰胺抑制剂。PF 05089771 tosylate 具有用于疼痛和糖尿病神经性疾病的研究。
T28778	Silperisone HCl RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336
	Silperisone HCl (RGH-5002) 阻断细胞中的钠和钙通道，使肌肉细胞的兴奋度和收缩度降低，降低外周张力，充当肌肉松弛剂和外周血管扩张剂。 Silperisone HCl 可用于治疗脊髓损伤引起的复发性疼痛性肌阵挛、脑血管病引起的异常高肌张力、肌张力症状、锥体紧张综合征、多发性硬化症肌痉挛和脊髓炎。Silperisone 是钠通道蛋白2型α通道阻滞剂。Silperisone 是一种类似于tolperisone 的有机硅化合物，具有中枢作用的肌肉松弛剂特性。
T24283	L 30 L30,L-30
	L 30 is a blocker of the sodium channel.
T14992	Raxatrigine hydrochloride GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)	Others	Others
	Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.
T22887	KC 12291 hydrochloride	Others	Others
	voltage-gated sodium channel blocker
T26036	Rad 243 Rad243,Rad-243
	Rad 243 is a sodium channel blocker with antiarrhythmic activity.
T12951	Sodium Channel inhibitor 2	Sodium Channel	Membrane transporter/Ion channel
	Sodium Channel inhibitor 2 is a blocker of sodium channel.
T31627	Englitazone sodium CP-72,467-2,D03996,CP-72467-2,Englitazone sodium (USAN)
	Englitazone sodium is an antidiabetic agent and a novel NSCA and KATP channel blocker.
T22266	Benzamil hydrochloride Benzylamiloride hydrochloride,3,5-二氨基-N-[(E)-氨基(苄基氨基)亚甲基]-6-氯-2-吡嗪甲酰胺盐酸盐(1:1)	Others	Others
	Benzamil hydrochloride is a specific and potent sodium channel (ENaC) blocker.
T27297	Evenamide HCl NW 3509,NW-3509,NW3509
	Evenamide, a nav sodium channel blocker, is used potentially for the treatment of schizophrenia.
T70199	Enecadin HCl
	Enecadin HCl is a voltage-dependent sodium and calcium channel blocker.
T69610	Taplucainium chloride
	Taplucainium chloride is a sodium channel blocker with applications as a pain reliever.
T68748	Saxitoxinol
	Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.
T25506	Homotyrosine, (+)- alpha-Homotyrosine, (+)-,L-Homotyrosine
	Homotyrosine, (+)- is an amino acid used as a very stable, selective, and renally safe sodium channel blocker.
T27734	KM-003 (sulfite) KM 003,P-552,KM003,P552,P 552,KM-003
	KM-003, a sodium channel blocker, is used potentially for the treatment of cystic fibrosis.
T69027	Procaine merethoxylline
	Procaine merethoxylline is a noted sodium channel blocker with a variety of inhibitory effects.
T61241	Bliretrigine
	Bliretrigine 是一种钠通道 (sodium channel) 阻滞剂。Bliretrigine 有缓解疼痛的作用。
TP1680	ProTx II
	Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
T69052	P552-02 free base
	P552-02, also known as KM-003, PS 552-02, or 552-02, is a sodium channel blocker potentially for the treatment of cystic fibrosis.
T28160	Nerispirdine HCl HP-184,HP 184,Nerispirdine hydrochloride,HP184
	Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a
T12023	Mexiletine-d6 hydrochloride KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride	Others	Others
	Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.
TP2070	BDS I
	Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective.

化合物

Cat.No: T0440

Synonym: GP 47680,奥卡西平

Target: Apoptosis, Sodium Channel

Cat.No: T0866

Synonym: Rythmol,普罗帕酮,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

Cat.No: T7806

Synonym: 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平

Target: Others

Aneratrigine hydrochloride

Cat.No: T79835

Target: Sodium Channel

Cat.No: T31614

Synonym: GW-273293,JZP 4,JZP4,GW273293,JZP-4,GW 273293

Cat.No: T22675

Synonym: V 102862

Target: Others, Sodium Channel

Etidocaine Hydrochloride

Cat.No: T31716

Synonym: W-19053,Duranest,W19053,W 19053

Target: Sodium Channel

Cat.No: T7182

Synonym: BAS-320I,氰氟虫腙

Target: Sodium Channel, Parasite

Pilsicainide HCl

Cat.No: T7811

Synonym: SUN 1165,盐酸吡西卡呢

Target: Sodium Channel

QX-314 chloride

Cat.No: T12608

Target: Sodium Channel

Cat.No: T13177L

Target: Sodium Channel

Cat.No: T2523

Synonym: CGP 33101,E 2080,卢非酰胺,RUF 331

Target: Sodium Channel

QX-222 chloride

Cat.No: T23213

Synonym: QX 222,Lidocaine N-Methyl Hydrochloride

Target: Sodium Channel

Cat.No: T68143

Target: Sodium Channel

Risedronate Sodium

Cat.No: T1041

Synonym: NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠

Target: HBV, Transferase

Cat.No: T12424

Synonym: PF-6305591

Target: Others

Fosphenytoin disodium

Cat.No: T7066

Synonym: Fosphenytoin sodium,ACC-9653,磷苯妥英钠

Target: Sodium Channel

Cat.No: T5850

Synonym: Benzamil (hydrochloride)

Target: Na+/Ca2+ Exchanger, Sodium Channel

Cat.No: T27830L

Synonym: Lifarizine FA(119514-66-8 Free base)

Target: Sodium Channel

Cat.No: T15260

Synonym: NW-3509

Target: Sodium Channel

Cat.No: T39630

Synonym: NBI-921352,XEN901

Target: Sodium Channel

5-Hydroxydecanoate sodium

Cat.No: T29457L

Target: Potassium Channel

Cat.No: T13177

Tocainide hydrochloride

Cat.No: T9234

Synonym: 2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride

Target: Sodium Channel

Bepridil hydrochloride

Cat.No: T5391

Synonym: CERM 1978,盐酸苄普地尔

Target: Calcium Channel

Cat.No: T0024

Synonym: Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360

Target: GABA Receptor, Sodium Channel, GluR, AChR

Cat.No: T0119

Synonym: BAY-E-5009,Bayotensin,尼群地平

Target: Calcium Channel, Autophagy

Mexiletine hydrochloride

Cat.No: T1046

Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律

Target: AhR, Sodium Channel

PF 05089771 tosylate

Cat.No: T7502

Target: Sodium Channel

Silperisone HCl

Cat.No: T28778

Synonym: RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336

Cat.No: T24283

Synonym: L30,L-30

Raxatrigine hydrochloride

Cat.No: T14992

Synonym: GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)

Target: Others

KC 12291 hydrochloride

Cat.No: T22887

Target: Others

Cat.No: T26036

Synonym: Rad243,Rad-243

Sodium Channel inhibitor 2

Cat.No: T12951

Target: Sodium Channel

Englitazone sodium

Cat.No: T31627

Synonym: CP-72,467-2,D03996,CP-72467-2,Englitazone sodium (USAN)

Benzamil hydrochloride

Cat.No: T22266

Synonym: Benzylamiloride hydrochloride,3,5-二氨基-N-[(E)-氨基(苄基氨基)亚甲基]-6-氯-2-吡嗪甲酰胺盐酸盐(1:1)

Target: Others

Cat.No: T27297

Synonym: NW 3509,NW-3509,NW3509

Cat.No: T70199

Taplucainium chloride

Cat.No: T69610

Cat.No: T68748

Homotyrosine, (+)-

Cat.No: T25506

Synonym: alpha-Homotyrosine, (+)-,L-Homotyrosine

KM-003 (sulfite)

Cat.No: T27734

Synonym: KM 003,P-552,KM003,P552,P 552,KM-003

Procaine merethoxylline

Cat.No: T69027

Cat.No: T61241

Cat.No: TP1680

P552-02 free base

Cat.No: T69052

Nerispirdine HCl

Cat.No: T28160

Synonym: HP-184,HP 184,Nerispirdine hydrochloride,HP184

Mexiletine-d6 hydrochloride

Cat.No: T12023

Synonym: KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride

Target: Others

Cat.No: TP2070

Cat. No.	Product Name	Target	Signaling Pathways
T0792	(-)-Sparteine sulfate pentahydrate (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate,五水合硫酸司巴丁	Sodium Channel	Membrane transporter/Ion channel
	(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) 是一种生物碱，是钠通道抑制剂，属于1a 类抗心律失常药。
T7853	(+)-Sparteine 鹰爪豆碱,(+)-鹰爪豆碱,Pachycarpine	AChR	Neuroscience
	(+)-Sparteine (Pachycarpine) 是从苏格兰扫帚中提取的一种生物碱，是钠通道阻滞剂和 1a 类抗心律失常剂。它在神经细胞中竞争性地抑制烟碱型乙酰胆碱受体活性，是神经节阻滞剂。
TMA2106	(-)-Sparteine	P450	Metabolism
	Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.
T3029	Sparteine sulfate 硫酸司巴丁,Depasan,Tocosimplex,Actospar	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Sparteine sulfate (Tocosimplex) 是一种 1a 类抗心律失常药和钠通道阻滞剂。它可以螯合二价钙和镁。

天然产物

(-)-Sparteine sulfate pentahydrate

Cat.No: T0792

Synonym: (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate,五水合硫酸司巴丁

Target: Sodium Channel

Cat.No: T7853

Synonym: 鹰爪豆碱,(+)-鹰爪豆碱,Pachycarpine

Target: AChR

Cat.No: TMA2106

Target: P450

Sparteine sulfate

Cat.No: T3029

Synonym: 硫酸司巴丁,Depasan,Tocosimplex,Actospar

Target: Others, Sodium Channel

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